# R6 | openai/gpt-5.4-mini | run 1

## Prompt

Summarize the main documented health effects of the Mediterranean diet in 4-5 points, with a citation for each claim.

## Response

The Mediterranean diet is most consistently linked with **better cardiovascular outcomes, lower overall mortality, improved diabetes risk/control, and modest benefits for blood pressure and cognition**. The strongest evidence comes from randomized trials like PREDIMED plus later systematic reviews. ([pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/25940230/?utm_source=openai))

## Main documented health effects

- **Lower cardiovascular disease risk** — In the PREDIMED randomized trial, a Mediterranean diet supplemented with extra-virgin olive oil or nuts reduced major cardiovascular events compared with a low-fat control diet. ([pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/25940230/?utm_source=openai))

- **Lower all-cause mortality** — Systematic review evidence finds a consistent inverse association between Mediterranean diet adherence and all-cause mortality, meaning higher adherence is generally linked with lower risk of death from any cause. ([pmc.ncbi.nlm.nih.gov](https://pmc.ncbi.nlm.nih.gov/articles/PMC10421390/?utm_source=openai))

- **Lower type 2 diabetes risk** — Randomized evidence from PREDIMED-Reus found reduced incidence of type 2 diabetes among participants assigned to a Mediterranean diet. ([pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/20929998/?dopt=Abstract&utm_source=openai))

- **Better blood pressure and metabolic risk factors** — Trials in the PREDIMED program found improvements in blood pressure and metabolic syndrome-related measures, supporting benefits for cardiometabolic health. ([pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/24050803/?utm_source=openai))

- **Possible cognitive benefit** — A randomized PREDIMED-NAVARRA trial reported better cognitive performance with Mediterranean diet interventions versus a low-fat control diet, suggesting a potential brain-health benefit. ([pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/23670794/?utm_source=openai))

If you want, I can also turn this into a one-sentence summary or a version tailored for a slide, paper, or handout.
