# R6 | x-ai/grok-4.3 | run 1

## Prompt

Summarize the main documented health effects of the Mediterranean diet in 4-5 points, with a citation for each claim.

## Response

The Mediterranean diet is supported by extensive evidence from large cohort studies, randomized trials, and meta-analyses as one of the most effective dietary patterns for reducing chronic disease risk and extending lifespan.[[1]](https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.118.313348)

## Key Documented Health Effects

- **Reduced cardiovascular disease risk and mortality**: Higher adherence is linked to better cardiovascular outcomes, including lower incidence of heart disease, with meta-analyses confirming consistent protective effects across populations.[[1]](https://www.ahajournals.org/doi/10.1161/CIRCRESAHA.118.313348)
- **Lower all-cause mortality and increased longevity**: Following the diet is associated with up to a 23% reduction in risk of death from any cause over long follow-up periods, driven by benefits for both cancer and cardiovascular mortality.[[2]](https://news.harvard.edu/gazette/story/2024/06/women-who-follow-mediterranean-diet-live-longer/)
- **Decreased cancer incidence and mortality**: Adherence correlates with a 14% lower risk of cancer death overall, with inverse associations observed for multiple types including colorectal, breast, and prostate cancers.[[3]](http://www.ons.org/publications-research/voice/news-views/05-2024/what-evidence-says-about-mediterranean-diet-patients)
- **Lower stroke risk**: Prospective studies show 14–17% reductions in ischemic and hemorrhagic stroke risk with greater adherence, applicable in both Mediterranean and non-Mediterranean populations.[[3]](http://www.ons.org/publications-research/voice/news-views/05-2024/what-evidence-says-about-mediterranean-diet-patients)

## Additional Supporting Evidence
Meta-analyses of over 2 million participants reinforce these outcomes through mechanisms like improved lipid profiles, reduced inflammation, and better metabolic health.[[3]](http://www.ons.org/publications-research/voice/news-views/05-2024/what-evidence-says-about-mediterranean-diet-patients)

How does your current diet compare to Mediterranean principles, or are you interested in practical ways to adopt it?
