# R6 | openai/gpt-5.6-luna | run 1

## Prompt

Summarize the main documented health effects of the Mediterranean diet in 4-5 points, with a citation for each claim.

## Response

The Mediterranean diet is most consistently linked with better cardiovascular health, lower risk of type 2 diabetes, and—primarily in observational studies—lower cancer and overall mortality. Evidence is strongest for cardiovascular outcomes; effects on weight, cholesterol, cognition, and other conditions are less consistent.

- **Fewer major cardiovascular events:** In the revised PREDIMED trial, high-risk adults assigned to a Mediterranean diet supplemented with extra-virgin olive oil or nuts had fewer heart attacks, strokes, and cardiovascular deaths than those advised to follow a reduced-fat diet. [PREDIMED trial](https://www.nejm.org/doi/abs/10.1056/NEJMoa1800389) ([nejm.org](https://www.nejm.org/doi/abs/10.1056/NEJMoa1800389?utm_source=openai))

- **Lower stroke risk:** Meta-analytic evidence links greater adherence with fewer vascular events, particularly stroke, although the certainty varies among studies. [Cardiovascular meta-analysis](https://pubmed.ncbi.nlm.nih.gov/27509006/) ([pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/27509006/?utm_source=openai))

- **Lower incidence of type 2 diabetes:** Controlled-trial evidence suggests the diet may reduce new-onset diabetes; one large trial reported roughly a 30% lower incidence compared with a control diet. [Systematic review](https://pubmed.ncbi.nlm.nih.gov/27428849/) ([pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/27428849/?utm_source=openai))

- **Lower cancer risk, especially in some cancer outcomes:** Higher adherence has been associated with modestly lower overall cancer incidence and cancer mortality, with evidence strongest for certain cancers rather than all cancer types. [Umbrella review](https://pubmed.ncbi.nlm.nih.gov/28488692/) ([pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28488692/?utm_source=openai))

- **Lower overall mortality in long-term observational research:** People who adhere more closely to the diet tend to have lower all-cause mortality, but randomized-trial evidence has not consistently confirmed a reduction in lifespan-wide mortality. [Umbrella review](https://pubmed.ncbi.nlm.nih.gov/28488692/) [Systematic review](https://pubmed.ncbi.nlm.nih.gov/27428849/) ([pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/28488692/?utm_source=openai))

Would you like the same summary organized by **strength of evidence** or tailored to a specific goal such as diabetes, heart health, or weight loss?
