# R6 | openai/gpt-5.6-luna | run 2

## Prompt

Summarize the main documented health effects of the Mediterranean diet in 4-5 points, with a citation for each claim.

## Response

The Mediterranean diet is most consistently linked with better cardiovascular and metabolic health. Evidence for lower mortality, cancer, and cognitive decline is promising but relies more heavily on observational studies and is therefore less conclusive.

- **Cardiovascular disease:** It is associated with fewer major vascular events, including heart attacks and strokes; randomized-trial evidence supports cardiovascular benefit, particularly when the diet includes extra-virgin olive oil or nuts. [1](https://pubmed.ncbi.nlm.nih.gov/27509006/) ([pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/27509006/?utm_source=openai))

- **Type 2 diabetes:** Greater adherence is associated with a lower risk of developing type 2 diabetes, with evidence suggesting a dose-response relationship. [2](https://pubmed.ncbi.nlm.nih.gov/41241045/) ([pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/41241045/?utm_source=openai))

- **Overall mortality:** People who adhere more closely to the diet tend to have a lower risk of death from any cause, although this finding is based mainly on prospective cohort studies rather than long-term randomized trials. [3](https://pubmed.ncbi.nlm.nih.gov/30401007/) ([pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/30401007/?utm_source=openai))

- **Cancer:** Higher adherence is associated with a modestly lower risk of overall cancer, but results vary by cancer type and the certainty of evidence is generally low. [4](https://pmc.ncbi.nlm.nih.gov/articles/PMC7987633/) ([pmc.ncbi.nlm.nih.gov](https://pmc.ncbi.nlm.nih.gov/articles/PMC7987633/?utm_source=openai))

- **Cognitive health:** Studies generally associate the diet with better global cognition and some memory measures; evidence that it prevents dementia or Alzheimer’s disease remains less certain. [5](https://pubmed.ncbi.nlm.nih.gov/35967772/) ([pubmed.ncbi.nlm.nih.gov](https://pubmed.ncbi.nlm.nih.gov/35967772/?utm_source=openai))

Would you like the same summary ranked by strength of evidence or adapted for a patient handout?
